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Uric acid rebound
I had high uric acid last month and took Febuxostat (Febutaz) continuously for about 30-40 days, after which my uric acid reduced to 4.7 mg/dL earlier it was 9.2. I stopped the medicine on 27 November, and after 20-25 days my uric acid has become elevated again. Why? I've been eating clean and strict diet food, completely veg protein, avoiding high purine food.
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The rise in your uric acid levels after stopping febuxostat is likely due to a rebound effect, which is common when discontinuing urate-lowering therapies like this medication. Febuxostat works by inhibiting an enzyme (xanthine oxidase) involved in uric acid production, effectively suppressing levels while you're taking it. However, it doesn't eliminate the underlying cause of your hyperuricemia—such as overproduction of uric acid in the body (due to genetics, metabolic factors, or other conditions) or reduced excretion by the kidneys. Once the drug is stopped, production can resume at the previous high rate, leading to a re-increase in serum uric acid, often within 1-3 weeks.
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Restricted protein intake, continuing febuxostat
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High uric acid can lead to various health issues. It can lead to gout, kidney stones, etc. Treatment is usually needed when there are symptoms. Need more information as to figure out why this happening .
Next Steps
Look out for any symptoms like joint pain , pain while urinating , etc . See a general physician.
Health Tips
Drink a lot of water
Avoid consuming red meat, alcohol(especially beer), sugary drinks.
Weight control is important
Exercise regularly.
This can keep your uric acid levels in check
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Please consult
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Need few more details for further evaluation. Please consult
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It could be familial.
Does anyone in your family have the same issue.
Have a low protein diet and adequate hydration upto 3 lt per day.
Treatment for hyperuricemia is usually long term.
Continue your meds, lifestyle modification and hydration.
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It is due to the genetic makeup of your body. You’ll have to continue Febustat in small doses even after uric acid levels are normal. Also avoid high protein diet. For further assessment you be can opt for a consultation with a physician.
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Avoid protein rich diet and continue medicine which prescribed
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High uric acid is due so lack of few enzyme in your body. So when ever you take some kind of proteins you will have high uric acid depending on how much you lack.. so you need to understand your body and diet and medicine.. consult on practo
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You may have to continue with febuxostat for long time.you can take prednisolone 20 mg twice daily for 7-10 days.Drink at least 2 litres of water daily, continue with the diet low in purine
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Your uric acid rose again because the disease mechanism is still active — the medicine was stopped too early.
Next Steps
if u have pre diabetes or Insulin resistance ,there is decrease renal uric acid excretion
things get aggravated if u have Stress
Poor sleep,
Abdominal fat,
Sedentary lifestyle,
Health Tips
Hyperuricemia is chronic, treatment must be continuous and monitored, not short-term.
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Avoid high protein diet, alcohol. Certain medications also increase uric acid. Need detailed history too. And for febuxostat you have to keep taking it for uric acid to control. Moreover all elevated uric acid levels doesn’t need treatment. You can consult for further assistance
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You need low purine diet
https://my.clevelandclinic.org/health/treatments/22548-gout-low-purine-diet
All the best.
J G S R clinic
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What is the veg protein you are taking ?
Do you consume alocohal ? And I have more questions feel free to consult
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Your uric acid increased again because febuxostat controls uric acid only while you are taking it. It does not cure the underlying problem of uric acid over-production or reduced excretion. Once the drug is stopped, uric acid often rebounds within 2–4 weeks, even if diet is strict.
Diet can reduce uric acid by only ~1 mg/dL
Next Steps
Restart urate-lowering therapy only after consulting a physician
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R u a chronic alcohol drinker?
Or r u consuming more red beef
Need more details.. Please connect me throgh practo or wattsap nine zero seven two two zero seven zero nine three
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What is the veg protein you are referring about and how much quantity of it are you consuming
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This is very common and not a failure on your part. Your response to Febuxostat was excellent (9.2 → 4.7), which means the drug works — it just needs adequate duration.
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Drink more water.
Take tab prednisone 20mg one daily for a week.
Tab Allopurinol 100mg one morning and one evening for 10 days..
Repeat uric acid and share results
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If you want to discuss your problem in more detail, feel free to message me on WhatsApp at nine one one nine two five five six nine nine for a free detailed discussion*
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Dr. Manoj Kumar
General Physician
10 yrs exp
Dehradun
Need few more details
Kindly consult
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Dr. Prasad Mankar
General Practitioner
Akola
Avoid high protein diet and continue the prescribed medication
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Dr. Gaurij Hood
General Physician
18 yrs exp
Valsad
Pls connect for further discussion and long term solution.
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Dr. Ravi Kumar Nadella
General Physician
18 yrs exp
Hyderabad
Limit veg protein too
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Dr. Sajid Ali
General Practitioner
4 yrs exp
Kanpur
Avoid protein rich diet
Continue with Febutaz medicine
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Dr. Anuj Mothsra
General Physician
6 yrs exp
Jhunjhunu
Can help you, kindly consult and provide detailed history for proper diagnosis and further management
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Dr. Abeed Ahmed
Diabetologist
11 yrs exp
Hyderabad
Your condition is called rebound flare . It means you have responded with drugs but after stopping again uric acid raised .. in such condition we have to continue medication for long duration like 3to 4 months depends ..if you have joint pains as well then add tab predinisolne 20 mg twice untill flare gone
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For more details consult on practo
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Dr. Vetsa Sri Krishna Chaitanya
General Physician
7 yrs exp
Rajahmundry
Need a few more details please consult for further evaluation and treatment
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Dr. Gaurav Jaiswal
General Physician
6 yrs exp
Jhansi
Avoid fried and spicy food
Water intake more
Do connect and consult
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Dr. Chaithra H
General Physician
5 yrs exp
Bangalore
Avoid protein
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.