I have been suffering from severe OCD and Anxiety for the last 5 years. It feels like a never ending battle. I have tried all the SSRIs along with some antipsychotic and other antidepressants made for OCD only like clomipramine, but I never got the relief I wanted but given me all the side-effects, I became unhealthy and gained 20 kgs of weight. Everything feels like a battle to me from locking the door to even paying someone or even talking with someone. Everything feels unreal I can't process anything normally. Is there any solution? Is there any new treatment available for these? I have also tried therapy.
Answers (7)
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What you’re experiencing sounds like treatment-resistant OCD, which doesn’t mean there is no solution, but that your approach needs to shift beyond standard medication and basic therapy. When OCD persists for years, the brain’s threat system becomes overactive and even simple tasks start feeling like battles, often accompanied by derealization where everything feels unreal or hard to process. Since you’ve already tried SSRIs, Clomipramine, and therapy without enough relief, the next step is to explore advanced options like intensive Exposure and Response Prevention (ERP), which needs to be structured and consistent, or newer treatments such as Transcranial Magnetic Stimulation (TMS), ketamine-assisted therapy, or glutamate-based medications like Memantine that work on different brain pathways. The key shift now is not giving up, but upgrading the treatment plan with a specialist who works specifically with resistant OCD, because many people in your position do improve when the strategy becomes more targeted and intensive.
Hello, I understand how difficult this must have been for you, especially after trying multiple treatments without adequate relief.
Some individuals with long-standing OCD may not respond fully to first-line medications, but there are still effective options available.
Next Steps
A detailed review by a psychiatrist is important to reassess diagnosis, previous medication trials (dose & duration), and adherence
Options like optimizing current treatment, combination strategies, or advanced treatments such as augmentation, intensive CBT (ERP), or neuromodulation (like rTMS in selected cases) may be considered
Health Tips
Continue structured therapy, especially Exposure and Response Prevention (ERP) with a trained therapist
Avoid reassurance-seeking and gradually resist compulsions
Maintain regular routine, sleep, and stress management
Don’t worry, with the right treatment you can improve. Kindly consult a psychiatrist (in person or online) for proper evaluation and management.
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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