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Splenomegaly, high b12, cirrhosis
Female,71, April 2025 routine check diagnosed compensated cirrhosis no symptoms. Less appetite Mild pedal edema. Biopsy /endoscopy, not done Taking nutritional cobadex, fdson d3, calcimax since 6 mnths. Lactulose. On Thyronorm for subclinical hypothyroidism, carvedilol 3.125 twice for liver n high bp, istamet for prediabetes. 1. Recent b12 test is 1255 high. Dr said continue supplements ??  2. Usgabdomen, 6 mnths back: shrunken right liver parenchymalchanges. Spleen 11.8 cm. Fibroscan 31 kpa,188 cap. AMA, ASMA,LKM1,HCH,HBSAG all neg. ANA positive 3+.IgG 24. Recent:Normal liver size altered echo texture, dilated channels around porta, 11 mm portalvein, spleen splenculus 21x16 mm. No ascites Low hb,rbc. Normal WBC, platelets, ptinr, AFP, electrolyte. Earlier elevated liver function r now normal except GGT of 40. # Query is anything to be done for *spleen, *high b12 ?? *Any portal vein issue as bp at times remains around 150/80. In a dilemma, as dr said nothing needs to b done!! 🙏
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Hi.. An Endoscopy and CECT Abdomen should be done at baseline evaluation for any patient with cirrhosis. Nothing needs to be done for high B12. You may stop vitamin supplements for a while. If BP is on a higher range, increase CARVEDILOL to 3.125mg in morning and 6.2g in evening. It can be increased to 6.25mg twice daily as well if BP continues to be on a higher range.
Next Steps
Get Upper GI Endoscopy and CECT Abdomen done
Health Tips
Consult a Liver Specialist
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Your reports suggest compensated liver cirrhosis, meaning your liver is affected but still maintaining its essential functions. There are no major red flags currently — no ascites, normal AFP, and stable blood counts — which are all good signs. 1. Spleen: Mild splenomegaly is expected in cirrhosis due to portal hypertension (increased pressure in the portal vein). The portal vein size of 11 mm is at the upper limit of normal and doesn’t need any intervention as long as there are no varices, bleeding, or low platelets. Continue carvedilol as it helps reduce portal pressure. 2. High B12: High serum B12 levels in liver disease are common because the damaged liver releases stored vitamin B12 into the blood. This does not indicate excess supplementation toxicity. You can stop additional B12 supplements for now and recheck levels after 2–3 months. 3. Blood Pressure / Portal Pressure: Blood pressure of 150/80 is slightly high; continue carvedilol and monitor regularly. Keep salt intake low and maintain hydration. 4. Liver Function & Follow-up: Since liver enzymes and AFP are stable and there’s no ascites, no invasive procedure is needed now. Continue periodic monitoring: • LFTs and renal function every 3 months • Ultrasound / Fibroscan every 6–12 months • Endoscopy once (to rule out varices, if not yet done)
Next Steps
• Avoid alcohol, unnecessary painkillers, and herbal medications. • Maintain a protein-rich, balanced diet unless advised otherwise. • Continue thyronorm, carvedilol, and other prescribed medicines. • Discuss with your hepatologist about screening endoscopy and hepatitis vaccinations (if not already done).
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Your condition appears stable and well-compensated. The goal is to monitor regularly and prevent progression. No urgent intervention is required at this stage.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.