My father was admit in hospital for head injury but now he got UTI i.e. nitrite positive in urine culture, he is on treatment inj Ceftriaxine, nitrofurantoin tablet, PCM tablet, but fever spikes are more in night, 48hrs has happened since this treatment, still there are spikes, l want opinion on this? Is there more additional treatment has to give or investigation has to be done? Am l missing something ?
Answers (29)
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Hello,
I am Dr. Romain Rajan, General Physician (Ex Govt Medical Officer at RML Hospital, New Delhi), and your case has been allotted to me.
Thank you for explaining the situation clearly. Your concern is valid, and Iâll address it step by step.
Understanding the current situation
Your father developed a UTI during hospital admission (very common after head injury, catheterisation, immobility).
A nitrite-positive urine suggests a bacterial UTI, usually gram-negative organisms.
He is currently on:
⢠Inj Ceftriaxone
⢠Nitrofurantoin
⢠Paracetamol
After 48 hours, it is not uncommon for fever spikes to still occur, especially at night, but this does warrant close review.
Possible reasons for persistent fever spikes
⢠Infection not yet fully controlled (48â72 hours is the usual window to see response)
⢠Organism resistant to current antibiotics
⢠Upper UTI or pyelonephritis
⢠Catheter-associated infection
⢠Another source of infection (lungs, blood, pressure sores)
⢠Post head-injury fever or central fever (important to consider)
What should be reviewed or investigated now
You are not missing anything, but at this stage doctors should consider:
⢠Urine culture and sensitivity report
â Most important to confirm if antibiotics are appropriate
⢠Blood tests
⢠CBC
⢠CRP or Procalcitonin
⢠Renal function tests
⢠Blood cultures if fever is high or persistent
⢠Chest evaluation if cough or low oxygen is present
⢠Review catheter
⢠Remove or change catheter if present
About treatment escalation
At this point:
⢠Do NOT change antibiotics blindly
⢠If fever persists beyond 72 hours or worsens, antibiotics may need upgradation based on culture
⢠Paracetamol will control fever but will not treat the cause
Red flags that need urgent escalation
⢠Fever >102°F repeatedly
⢠Drop in BP or urine output
⢠Altered sensorium
⢠Rising creatinine
⢠Signs of sepsis
Important reassurance
Persistent fever at 48 hours does not mean treatment has failed, but it does mean reassessment is needed, especially culture-based decision making.
You are asking the right questions at the right time.
If you want, you can share:
⢠Age of your father
⢠Whether catheter is present
⢠Culture report (if available)
⢠Latest vitals
For a one to one discussion and guidance on investigations or antibiotic strategy, you can reach out to me on WhatsApp at 85271646 seven seven.
Wishing your father a smooth recovery.
Correct Antibiotics given after the culture report, usually takes around 2 days to show the results.If the fever lasts beyond 2-3 days,it could be catheter induced infection or other associated conditions.His doctor may repeat the necessary blood tests
Need more info in urine culture
Check for which antibiotic sensitive and resistant
If catheterized, change the catheter
If still persist look for Dengue, Malaria and widal and CRP, WBC count
In elderly patients, fever due to UTI may take 48–72 hours to settle even after starting antibiotics, so persistent fever at 48 hours does not always mean treatment failure; however, it is important to review urine culture and sensitivity, ensure the antibiotic matches the organism, and check for factors that delay recovery such as diabetes, urinary catheter, prostate enlargement, urinary retention, kidney involvement, or another infection source. Additional tests like CBC, CRP, kidney function tests, blood culture (if fever persists), ultrasound KUB, and HbA1c (as diabetes worsens UTI) may be needed, and antibiotics should be adjusted based on reports rather than adding medicines blindly. Close monitoring by the treating team is advised, and if fever continues beyond 72 hours or condition worsens, further evaluation is necessary.
Some more information is required.....
Whether he is catheterized or not....
If he is catheterized then which cather is used...
If he is on simple foley's cather then it should be changed every in 15days.
If he is able to pass urine himself then cather can be removed(which can be a source of infection)
If his consciousness is altered but he is able to pass urine himself then malecath can be used.
Antibiotic according to urine culture should be given.
Repeat CBC and Urine culture is advisable.
Oher source of fever must be ruled out.
You can ask the team looking after your father about the following,
1. Blood cultures
2. Screened for infections elsewhere like chest, abdomen, joints and CNS site etc
3. Any concerns re multi-resistant bacteria
All the best.
J G S R Clinic
It will take some time but you will see the fever gap increasing with decreased levels of fever that will mean the medication is working
Check the temperature charts
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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