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Forms and strengths, route of administration – 500 mg (10 mg/ml, 50 ml) and 1 g (10 mg/ml, 100 ml) vials, for infusion Dosage – Neonate: 7.5 mg/kg (0.75 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily) – Child ≥ 1 month and < 10 kg: 10 mg/kg (1 ml/kg) every 6 hours, to be administered over 15 minutes (max. 30 mg/kg daily) – Patient ≥ 10 kg and < 50 kg: 15 mg/kg (1.5 ml/kg) every 6 hours, to be administered over 15 minutes (max. 60 mg/kg daily) – Patient ≥ 50 kg: 1 g (100 ml) every 6 hours, to be administered over 15 minutes (max. 4 g daily) Duration – According to clinical response. Change to oral route as soon as possible. Contra-indications, adverse effects, precautions – Do not administer to patients with severe hepatic impairment. – Administer with caution to patients with moderate hepatic impairment, severe renal impairment, chronic alcoholism, malnutrition, dehydration. – May cause (very rarely): malaise, hypotension and rash. – Do not exceed indicated doses, especially in children and elderly patients. Paracetamol intoxications are severe (hepatic cytolysis). – Pregnancy: no contra-indication – Breast-feeding: no contra-indication Remarks – As the efficacy of IV paracetamol is not superior to the efficacy of oral paracetamol, the IV route is restricted to situations where oral administration is not possible. – For mild pain, IV paracetamol is used alone or in combination with an NSAID administered parenterally. – For moderate pain, IV paracetamol is used in combination with an NSAID and tramadol administered parenterally. – For severe pain, IV paracetamol is used in combination with an NSAID and morphine administered parenterally. – Paracetamol has no anti-inflammatory properties. – Do not mix with other drugs in the same infusion bottle. – Storage: below 25 °C -