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Combination of medicine
My doctor suggested to me, desvenlafaxine 50mg at night and paroxitine at morning. Shall i take both at night? Any side effects occur?
Answers (10)
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It is advisable to follow the given prescription and raise query with prescribing doctor regarding this. Kindly avoid making changes to your prescription without supervision.
Each prescription is tailored based on the individuals consultation and history provided to the treating psychiatrist.
If your query remains unresolved then persue a second opinion online or offline.
Next Steps
follow up with consulting psychiatrist, if query remains unresolved persue second opinion.
Health Tips
avoid making changes to prescription without medical supervision
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Hello,
Desvenlafaxine and paroxetine are both antidepressants but usually prescribed to be taken at different times—desvenlafaxine at night and paroxetine in the morning—because of their effects and side effect profiles.
Taking both together at night may increase side effects like dizziness, drowsiness, or nausea.
Always follow your doctor’s instructions. If you want to change the timing, discuss it with your doctor first to avoid any issues.
If you notice unusual side effects, contact your doctor promptly.
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Dose of paroxetine you have not mentioned .. can be taken no issues
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Consult psychiatrist if any discomfort or any side effects you experience
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Heyy
I can help you better with further treatment course needed. U can connect me via whatsapp on seven zero eight two zero two two zero six two.
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Desvenlafaxine and paroxetine are both antidepressants but belong to different classes (SNRI and SSRI respectively). Taking both together can be appropriate in some cases under careful medical supervision. Your doctor advised desvenlafaxine at night and paroxetine in the morning likely to optimize therapeutic effects and reduce side effects.
Taking both at night may increase the risk of sedation, dizziness, or serotonin-related side effects like agitation, tremor, or gastrointestinal upset. It is best not to change the timing of your medications without discussing it with your prescribing doctor.
Next Steps
Please continue with the prescribed timing unless you are experiencing side effects. If you feel sedated or have trouble sleeping, report it to your doctor to consider dose adjustment or an alternative plan.
Health Tips
1. Avoid alcohol while on these medications.
2. Monitor for symptoms like restlessness, sweating, confusion, or unusual behavior, and report them immediately.
3. Don't stop or change the medication timing without professional guidance.
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As per my opinion, you can take both medications at night, there is no issue in taking it both at night, Along with it you should also follow sleep hygiene, DBR.When a person follow healthy lifestyle that are also called non pharmacological management along with medication, response is better, regarding this you can discuss with your psychiatrist further
Next Steps
you can discuss with your doctor
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whenever you plan follow up visits, discuss key points first with your doctor to solve your query
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Hi.. will need further history regarding the same to advise appropriately. Consult online for further evaluation and management
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Dr. Parika Kochhar
Psychiatrist
7 yrs exp
Noida
It is better to take such medicines as prescribed by your doctor. Each medicine has a particular role to play at a particular time of the day. In psychiatry medicines are always tailored according to the patient. In case you are experiencing any side effects, you can of course ask the doctor to change the medicines accordingly.
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Dr. Myle Muralidhar
Psychiatrist
7 yrs exp
Kurnool
Based on the history provided, both medications increases the serotonin in the brain. I suggest Paroxetine at night because it increases the drowsiness and Desvenlafaxine in the morning because it is little activating agent. Avoid taking both together. There will be certain side effects like sleep disturbances etc.
"Since you're on two medicines that affect brain serotonin, there's a small risk of something called serotonin syndrome. Itâs rare but serious. Watch out for symptoms like restlessness, tremors, fever, confusion, or heavy sweating. If any of these happenâespecially in combinationâstop the medicines and seek emergency care immediately."
Next Steps
Take medications as suggested and watch for side effects
Health Tips
Take medicines exactly as prescribed â Never increase the dose or take both together at night without consulting your psychiatrist. Avoid other serotonergic substances â No over-the-counter cold meds, painkillers like tramadol, or herbal supplements (e.g., St. John's Wort) without medical advice. Donât mix with alcohol or recreational drugs â Increases risk of side effects and serotonin syndrome. Inform every doctor you're seeing that youâre on these medications, especially in case of surgery or emergency visits.
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Dr. Sunil Nagar
General Physician
18 yrs exp
Rewa
Kindly connect
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.