Arterial Blockage. Arterial blockage?

Hi, My brother is 27 years old. His lifestyle is very much sedantry as he is a software professional who spends most of the time in front of computers. Since two years he is having high cholesterol. Below are the values in his latest report : Cholesterol - 215 mg/dL Triglycerides - 158 mg/dL HDL Cholesterol - 42 mg/dL Direct LDL Cholesterol - 154 mg/dL Non HDL Cholesterol - 173 mg/dL CHOL/HDL ratio - 5.1 LDL/HDL ratio - 3.7 Very Low Density Lipoprotein - 31.6 mg/dL He just wants to know how badly his heart will be affected by having such cholesterol levels continuously for 2 years. What are the chances that plaque has been deposited in his arteries resulting in blockage? And which tests should he go for to detect arterial blockage?