I took phenytoin 300mg er till 8/2/25, and liver test was abnormal from 17/2/25 8/2/25-alt 15 ast 19
17/2/25-alt 94 ast 73 19/2/25-alt 80 ast 46
24/2/25-alt 166 ast 71 28/2/25-alt 148 ast 60
25/3/25-alt 204 ast 48 GGT 192 but no jaundice and alp elevated 2/4/25-alt-18 ast 84 Doctors ruled out other causes. is the abnormal liver test due to phenytoin
Answers (12)
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Phenytoin does cause liver toxicity. Can help you, just provide details as to duration of taking phenytoin? Dose? For what kind of seizures you are taking it,?
Meanwhile stop phenytoin. You can take tab prednisone 20mg one in morning for a week.
Then instead of phenytoin some other tablet can be started.
Yes it could be due to phenytoin as it is known hepatotoxic drugs
Also there is temporal relationship between
readings according to phenytoin administration and stoppage.
Next Steps
If seizures need management, consider safer alternatives like levetiracetem or lamotrigine after consulting with medicine speciallist
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