Will JAC2(v617f) be negative after medic

Question

Asked for Female, 33 Years

My mother is diagnosed with JAC2(v617f) positive. Her platelet count is always in the range 5 lakh to 6lakh but not more than that. Heamatologist prescribed her to take hydroxyurea 500mg tablet. My question is 1.whether JAC2(V617F) will become negative after certain duration of treatment? 2.Is it a hereditary disease if so then when should others in the family should take test or any other symptoms?

Answers (1)

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Dr. Savio James Radiation Oncologist 8 yrs exp Cochin · Accepted Answer

Dr. Savio James

Radiation Oncologist 8 yrs exp Cochin

No JAK2 won’t get negative , treatment is to avoid the complications. This can be a spontaneous mutation that caused trouble in JAK2, such spontaneous changes won’t be transmitted and may not cause risk in family line . But if you are having family history , then yes it can be heritable- it’s an autosomal dominant transmission - so 50 % children of one diseased parent may harbour the disease . You can consult me with your family tree or history if you want to discuss this further

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